tools
Origin-1
Origin-1 designs full-length antibodies for targets with no known protein binders or structural complex data.
Origin-1 is Absci's generative AI platform for designing full-length monoclonal antibodies against “zero-prior” epitopes. It combines structure generation, antibody sequence design, candidate scoring, and filtering before experimental testing.
Absci uses it for therapeutic discovery and lead identification. The platform has been validated with binding, specificity, developability, functional, and cryo-EM assays. Absci does not publish self-serve pricing; commercial terms and any additional laboratory services are not listed.
Features
- Designs full-length monoclonal antibodies against zero-prior epitopes
- AbsciDiff generates antibody-antigen complex structures
- IgDesign2 designs all six antibody complementarity-determining regions
- AbsciBind scores and filters candidates before experiments
- Screens fewer than one hundred designs per target
- Uses SPR, BLI, SEC, and developability assays for validation
- Includes a public code and data repository under the MIT license
Use cases
- Design antibodies against targets with no known protein binders
- Identify binders for previously uncharacterized epitopes
- Screen candidate antibodies for specificity and developability
- Validate predicted antibody-antigen structures with cryo-EM
- Optimize weak binders through AI-guided affinity maturation