tools
IgDesign
IgDesign designs antibody CDR sequences from antibody-antigen structures for binder discovery and lead optimization.
IgDesign is an antibody inverse-folding model from Absci. It takes antibody-antigen structures, antigen sequence, and antibody framework sequences as context, then generates candidate complementarity-determining region sequences.
Researchers use it for de novo antibody design and lead optimization. The public release is software and pretrained model weights rather than a hosted design service; running it requires local setup and compatible GPU hardware. No official pricing page was found.
Features
- Designs HCDR3 or all three heavy-chain CDRs
- Uses antibody-antigen structures as model input
- Conditions designs on antigen and antibody framework sequences
- Combines IgMPNN structural encoding with ESM2-3B sequence decoding
- Generates sequences and optional cross-entropy scores in CSV output
- Includes SPR validation datasets and representative sensorgrams
- Supports NVIDIA CUDA and AMD ROCm environments
- Released under the MIT license
Use cases
- Design antibody CDR sequences for therapeutic targets
- Optimize antibody leads against known antigen structures
- Screen generated antibody libraries for binding
- Compare inverse-folding designs with biological sequence baselines
- Run antibody sequence generation from PDB structures