tools
Chai-2
AI protein-design model for generating de novo antibodies, nanobodies, miniprotein binders, and epitope-specific designs.
Chai-2 generates protein binders from target structures or sequences. It supports antibody formats including mAbs, VH-VL, VHH, scFvs, nanobodies, and miniproteins, with controls for epitopes, antigen states, chemical modifications, species specificity, and cross-reactivity.
It is intended for academic and commercial drug-discovery organizations. Access requires an application; academic access is described as limited and non-commercial. No public self-serve pricing was listed.
Features
- Designs de novo antibodies and miniprotein binders
- Supports mAbs, VH-VL, VHH, scFv, and nanobody formats
- Uses public or private target structures and supplied sequences
- Targets selected, small, buried, or non-immunogenic epitopes
- Handles ligands and post-translational modifications such as glycans
- Controls species or ortholog specificity and cross-reactivity
- Targets membrane proteins and specific antigen states
Use cases
- Design antibodies against challenging or novel protein targets
- Target a defined epitope on a protein structure
- Generate binders for membrane proteins and GPCRs
- Engineer agonist or antagonist antibodies against a target state
- Design binders around ligands or post-translational modifications