tools
Chai-1
Chai-1 predicts molecular structures and interactions across proteins, small molecules, DNA, RNA, and covalent modifications.
Chai-1 is a multimodal foundation model for molecular structure prediction. It can predict proteins, small molecules, DNA, RNA, covalent modifications, and multimolecular interactions, including from single sequences without multiple sequence alignments.
Researchers and drug-discovery teams can use it through Chai Discovery's web interface or run the released software library and model weights. The web interface is free, while the official site does not list paid tiers or commercial pricing. Chai Discovery has since introduced newer model series, including Chai-2.
Features
- Predicts structures for proteins, small molecules, DNA, and RNA
- Models covalent modifications and other molecular components
- Predicts multimer structures from single sequences without MSAs
- Supports epitope conditioning and laboratory-derived restraints
- Provides a web interface for model access
- Releases model weights and inference code
- Software library released under the Apache 2.0 License
Use cases
- Predict protein and biomolecular structures for research
- Model antibody–antigen interactions and epitope contacts
- Explore molecular interactions relevant to drug discovery
- Run structure prediction without multiple sequence alignment searches
- Test predictions using laboratory-derived molecular restraints
Pros
Cons
Latest updates
- Chai Discovery Announces Collaboration with GSK Following Successful Wet-Lab Evaluation
Collaboration with GSK following wet-lab evaluation.
- Chai Discovery Announces Collaboration with Bristol Myers Squibb to Advance AI-Driven Antibody Discovery
Collaboration with Bristol Myers Squibb to advance antibody discovery.
- Chai Discovery Enters Into Collaboration Agreement With argenx to Advance AI-Driven Immunology Breakthroughs
argenx will gain access to Chai’s AI platform.
- Chai Discovery Announces Collaboration with Novartis to Advance AI-Driven Antibody Discovery
Novartis will gain access to Chai Discovery’s AI design models and platform.
- Chai Discovery Collaborates with Lilly TuneLab to Offer AI Capabilities to Select Biotechs
Enables biotechs to evaluate Chai’s miniprotein design suite.
Pricing
- Starting price
- Free
- Prices checked
- 2026-10-27
- Read
- by web search
Free
Free
- Available via web interface (lab.chaidiscovery.com)
- Includes commercial use (e.g. drug discovery)
- Model weights and inference code released under Apache 2.0 (github.com/chaidiscovery/chai-lab)